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Imperfections in the research methodology and reporting limit the interest that can be generated among researchers outside China to pursue the Chinese herb treatment of liver fibrosis in greater detail. Large amounts of hyaluronic acid deposited in the liver blood sinus is the key basis of liver fibrosis and portal hypertension formation. One of the proposed mechanisms is to inhibit the hepatic stellate cells that proliferate and contribute substances to the hepatic extracellular matrix, forming the fibrotic mass.

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